Solid-phase synthesis of Delta(2)-isoxazolines

Solid-phase synthesis of Delta(2)-isoxazolines through a 1,3-dipolar cycloaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophiles to afford Delta(2)-isoxazolines in good yie...

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Bibliographic Details
Published inTetrahedron letters Vol. 39; no. 9; pp. 939 - 942
Main Authors Cheng, JF, Mjalli, AMM
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 26.02.1998
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
POLYMER-SUPPORTED SYNTHESIS
ELECTROPHILIC CYCLIZATION
CYCLIC ETHERS
NITRILE OXIDES
3+2 CYCLOADDITION
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Summary:Solid-phase synthesis of Delta(2)-isoxazolines through a 1,3-dipolar cycloaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophiles to afford Delta(2)-isoxazolines in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/S0040-4039(97)10700-6