A convenient synthesis of alpha-hydroxyiminoacetonitriles from aldoximes

Aromatic alpha-hydroxyiminoacetonitriles can be conveniently prepared by a facile one-pot procedure in high yields involving chlorination of the corresponding aldoximes with tert-butyl hypochlorite followed by reaction with alkali cyanide.

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Bibliographic Details
Published inSynthetic communications Vol. 29; no. 22; pp. 3863 - 3868
Main Authors Ma, JA, Ma, ZH, Ma, HM, Huang, RQ, Shao, RL
Format Journal Article
LanguageEnglish
Published NEW YORK Marcel Dekker Inc 01.01.1999
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Aromatic alpha-hydroxyiminoacetonitriles can be conveniently prepared by a facile one-pot procedure in high yields involving chlorination of the corresponding aldoximes with tert-butyl hypochlorite followed by reaction with alkali cyanide.
ISSN:0039-7911
DOI:10.1080/00397919908085906