HMDS-promoted in situ amidation reactions of carboxylic acids and amines

A number of N-acylalkylenediamines were synthesized in high yields by in situ monoamidation of carboxylic acids with diamines. The amidation reactions were carried out simply by heating the substrates at 110 degrees C for 5-24 h in the presence of HMDS. (C) 1999 Published by Elsevier Science Ltd. Al...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 40; no. 17; pp. 3419 - 3422
Main Authors Chou, WC, Chou, MC, Lu, YY, Chen, SF
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 23.04.1999
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
REAGENTS
Online AccessGet full text

Cover

More Information
Summary:A number of N-acylalkylenediamines were synthesized in high yields by in situ monoamidation of carboxylic acids with diamines. The amidation reactions were carried out simply by heating the substrates at 110 degrees C for 5-24 h in the presence of HMDS. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/S0040-4039(99)00505-5