A facile synthesis of a useful 5-N-substituted-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid from 2-acetamido-2-deoxy-D-glucose

The chemoenzymic synthesis of the sialic acid Neu5Boc from the commercially-available carbohydrate N-acetyl-D-glucosamine is presented, A basic resin-catalysed epimerisation of N-acetyl-D-glucosamine to N-acetyl-D-mannosamine is also discussed. (C) 1997 Elsevier Science Ltd.

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Bibliographic Details
Published inCarbohydrate research Vol. 300; no. 2; pp. 171 - 174
Main Authors Wu, WY, Jin, B, Kong, DCM, vonItzstein, M
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 12.05.1997
Subjects
Biochemistry & Molecular Biology
Chemistry
Chemistry, Applied
Chemistry, Organic
Life Sciences & Biomedicine
Physical Sciences
Science & Technology
chemoenzymic synthesis
ESCHERICHIA-COLI
ENZYMATIC-SYNTHESIS
ALDOLASE
epimerisation
sialic acid
ENZYMES
N-acetyl-D-hexosamine
INFLUENZA-VIRUS
INHIBITORS
SIALIC ACIDS
N-ACETYLNEURAMINIC ACID
LYASE
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Summary:The chemoenzymic synthesis of the sialic acid Neu5Boc from the commercially-available carbohydrate N-acetyl-D-glucosamine is presented, A basic resin-catalysed epimerisation of N-acetyl-D-glucosamine to N-acetyl-D-mannosamine is also discussed. (C) 1997 Elsevier Science Ltd.
ISSN:0008-6215
DOI:10.1016/S0008-6215(97)00020-7