Ultrasound promoted synthesis of (+/-)-8-hydroxy-5-isopropyl-8-methyl-6(E)nonen-2-one ((+/-)-solanone hydrate) and 3,7-dimethyl-2(E),7-octadienylpropionate

A facile synthesis of the title compounds has been accomplished using Zn-Cu couple catalyzed conjugate addition of allylic halides to alpha,beta-unsaturated ketones initiated by ultrasonic waves under aqueous conditions and Horner-Wittig reaction using ethyl alpha-dimethylphosphonoacetate and NaH as...

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Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 43; no. 9; pp. 1950 - 1953
Main Authors Singh, Chaudhary, S, Sapehiyia, Kaur, Kad, GL, Singh, J
Format Journal Article
LanguageEnglish
Published NEW DELHI Natl Inst Science Communication & Information Resources-Niscair 01.09.2004
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SCALE
ISOMERIC COMPONENTS
IDENTIFICATION
SOLANONE
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Summary:A facile synthesis of the title compounds has been accomplished using Zn-Cu couple catalyzed conjugate addition of allylic halides to alpha,beta-unsaturated ketones initiated by ultrasonic waves under aqueous conditions and Horner-Wittig reaction using ethyl alpha-dimethylphosphonoacetate and NaH as base in dry THF as the key steps in overall good yields.
ISSN:0376-4699
0019-5103