Translational Biomarkers of Acute Drug‐Induced Liver Injury: The Current State, Gaps, and Future Opportunities

This chapter contains sections titled: Intrinsic and Idiosyncratic Drug‐Induced Liver Injury: Terminologies and Background Histological Manifestations of Liver Injury Common Mechanisms of Acute Liver Injury Processes of Hepatocyte Cell Death Traditional Preclinical and Clinical Biomarkers of Drug‐In...

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Bibliographic Details
Published inBiomarkers pp. 203 - 236
Main Authors Ozer, Josef S, Reagan, William J, Schomaker, Shelli, Palandra, Joe, Baratta, Mike, Ramaiah, Shashi
Format Book Chapter
LanguageEnglish
Published Hoboken, NJ, USA John Wiley & Sons, Inc 20.09.2010
Subjects
acute drug‐induced liver injury
cholestatic liver injury
hepatic steatosis
hepatocyte cell death
translational biomarkers
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Summary:This chapter contains sections titled: Intrinsic and Idiosyncratic Drug‐Induced Liver Injury: Terminologies and Background Histological Manifestations of Liver Injury Common Mechanisms of Acute Liver Injury Processes of Hepatocyte Cell Death Traditional Preclinical and Clinical Biomarkers of Drug‐Induced Liver Injury Gaps in Traditional Hepatic Biomarkers Considerations to Predict Acute Liver Injury: Anatomy and Time‐Course New and Emerging Serum Enzyme Biomarkers of Liver Injury ALT Isozymes: ALT1 and ALT2 ALT Protein Levels in Serum Current Knowledge on Biology of ALT Does Metabolic Syndrome Illicit a Conflicting ALT Signal for DILI? Anorexia Shows Metabolic Indicators of Liver Injury Including Subtle ALT Elevations Biomarkers of Biliary Injury Authors' Opinion on Future Biomarkers of Liver Injury, Novel Approaches, and Platforms Unification of Diagnostic Metrics of Liver Fibrosis Analytical Biomarker Platforms to Assay Serum Biomarkers of Liver Injury Conclusions Acknowledgments Summary Points
ISBN:0470452242
9780470452240
DOI:10.1002/9780470918562.ch9