Synthesis of (−)‐[18F]Flubatine ([18F]FLBT)

• Published in: Radiochemical Syntheses pp. 1 - 11
• Main Authors: Stewart, Megan N, Hockley, Brian G, Scott, Peter J. H
• Format: Book Chapter
• Language: English
• Published: Hoboken, NJ John Wiley & Sons, Inc 22.05.2015
• Subjects: endotoxin analysis; flubatine; radiochemical identity; radionuclidic identity; residual kryptofix 222 analysis; sterile filter integrity; sterility testing; visual inspection

The development of (‐)‐[ 18 F]flubatine as a high affinity and selective PET radiotracer with improved kinetics over the earlier developed ligands allows for non‐invasive quantification of a4ß2‐nicotinic acetylcholine receptors (a4ß2‐nAChRs). This chapter discusses the synthesis procedures for (‐)‐[...