Synthesis of (−)‐[18F]Flubatine ([18F]FLBT)

The development of (‐)‐[ 18 F]flubatine as a high affinity and selective PET radiotracer with improved kinetics over the earlier developed ligands allows for non‐invasive quantification of a4ß2‐nicotinic acetylcholine receptors (a4ß2‐nAChRs). This chapter discusses the synthesis procedures for (‐)‐[...

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Bibliographic Details
Published inRadiochemical Syntheses pp. 1 - 11
Main Authors Stewart, Megan N, Hockley, Brian G, Scott, Peter J. H
Format Book Chapter
LanguageEnglish
Published Hoboken, NJ John Wiley & Sons, Inc 22.05.2015
Subjects
endotoxin analysis
flubatine
radiochemical identity
radionuclidic identity
residual kryptofix 222 analysis
sterile filter integrity
sterility testing
visual inspection
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Summary:The development of (‐)‐[ 18 F]flubatine as a high affinity and selective PET radiotracer with improved kinetics over the earlier developed ligands allows for non‐invasive quantification of a4ß2‐nicotinic acetylcholine receptors (a4ß2‐nAChRs). This chapter discusses the synthesis procedures for (‐)‐[ 18 F]flubatine. All radiochemical syntheses must be carried out using appropriate equipment in a facility authorized for the use of radioactive materials. It discusses quality control (QC) procedures for (‐)‐[18F] FLBT, based upon the current requirements for radiopharmaceuticals laid out in the US Pharmacopeia (USP). The parameters assessed in quality control procedures include visual inspection, radiochemical identity, radiochemical purity, specific activity, residual solvent analysis, dose pH, residual kryptofix 222 analysis, sterile filter integrity test, radionuclidic identity, endotoxin analysis and sterility testing. All hazardous chemicals and toxic materials were disposed of according to prudent practices in the laboratory.
ISBN:9781118237847
1118237846
DOI:10.1002/9781118834114.ch1