CuCl2 or I2/DMSO Catalyzed S‐S Bond Cleaving/Cyclization Reactions to Synthesize 2‐Arylbenzothiazoles via 2,2′‐Disulfanediyldianilines and Aromatic Aldehyde

• Published in: ChemistrySelect (Weinheim) Vol. 7; no. 7
• Main Authors: Lu, Qichao, Zhao, Lingyu, Wu, Lingang, Wang, Xiangqian, Shen, Guodong, Huang, Xianqiang, Du, Mengcheng, Ma, Delong
• Format: Journal Article
• Language: English
• Published: 18.02.2022
• Subjects: 2-arylbenzothiazoles; cleaving; cyclization; synthetic method; S−S bond
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202104081

Two feasible and convenient S−S bond cleaving/cyclization reactions for the synthesis of 2‐arylbenzothiazoles catalyzed by CuCl2 or I2/DMSO via 2,2′‐disulfanediyldianilines and aromatic aldehydes have been reported. The reactions are compatible with a range of substrates and could successfully generate 2‐arylbenzothiazoles in moderate to excellent yields, respectively. For the reactions, ‘one‐pot’ conditions were applied and readily available starting materials were employed. The importance of the protocols were attractive for synthetic method. In this paper, two convenient S−S bond cleaving/cyclization reactions for the synthesize of 2‐arylbenzothiazoles catalyzed by CuCl2 or I2/DMSO via 2,2′‐disulfanediyldianilines and aromatic aldehydes have been developed. The reactions used readily available starting materials and simple ‘one‐pot’ operation, exhibited functional group tolerance. The importance of this method would render this protocol attractive for synthetic chemistry.