Baclofen

In the central nervous system, γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter. Three major GABA receptors – GABAA, GABAB, and GABAC – have been identified. Baclofen (β-(4-chlorophenyl)-γ-aminobutyric acid) is a GABA agonist, specific to GABA at therapeutic doses, that has been us...

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Bibliographic Details
Published inCritical Care Toxicology pp. 1119 - 1131
Main Authors Stewart, Erin, Tormoehlen, Laura M.
Format Book Chapter
LanguageEnglish
Published Cham Springer International Publishing 2017
Subjects
Baclofen
Baclofen withdrawal
Brain death
Flumazenil
GABA
GABA receptors
Ondansetron
receptors
γ-aminobutyric acid
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Summary:In the central nervous system, γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter. Three major GABA receptors – GABAA, GABAB, and GABAC – have been identified. Baclofen (β-(4-chlorophenyl)-γ-aminobutyric acid) is a GABA agonist, specific to GABA at therapeutic doses, that has been used to treat spasticity of various etiologies (e.g., multiple sclerosis, paraplegia, quadriplegia, cerebral palsy). It has also been used off-label for dystonia, jerking, restless legs, chorea, stiff-person syndrome, torticollis, tetanus, hiccups, trigeminal neuralgia, cluster headaches, and musculoskeletal pain; with more recent investigations for the management of rumination, supragastric belching, and gastroesophageal reflux; alcohol, opioid, and cocaine abuse disorders; bladder spasm; and in combined use with antimuscarinic agents for overactive bladder [1–28].
ISBN:9783319178998
3319178997
DOI:10.1007/978-3-319-17900-1_136