Cardiac Modeling for Multisystem Inflammatory Syndrome in Children (MIS-C, PIMS-TS)

• Published in: Functional Imaging and Modeling of the Heart pp. 435 - 446
• Main Authors: Waugh, Rebecca, Hussein, Mohamed Abdelghafar, Weller, Jamie, Sharma, Kavita, Greil, Gerald, Kahn, Jeffrey, Hussain, Tarique, Chabiniok, Radomír
• Format: Book Chapter
• Language: English
• Published: Cham Springer International Publishing
• Series: Lecture Notes in Computer Science
• Subjects: Cardiac modeling; Cardiovascular magnetic resonance imaging (CMR); Circulatory shock; Echocardiography; Heart failure; Intensive Care Unit (ICU) monitoring; Multisystem Inflammatory Syndrome in Children (MIS-C PIMS-TS)
• ISBN: 9783030787097; 3030787095
• ISSN: 0302-9743; 1611-3349
• DOI: 10.1007/978-3-030-78710-3_42

Cardiovascular data of 8 patients with Multisystem Inflammatory Syndrome in Children (MIS-C), caused by an aberrant reaction of immune system to the SARS-CoV-2 coronarovirus, were retrospectively analyzed by using patient-specific biomechanical modeling. The first goal was to increase the understanding of the pathophysiology of the cardiovascular involvement in MIS-C, during the inpatient stay at Intensive Care Unit and after discharge from the hospital. Secondly, hypothetical action of various types of pharmacological therapy was tested in silico using the created patient-specific models, aiming to contribute into the optimal pharmacological management during the acute stage of MIS-C.