Encefalopatia hipóxico-isquêmica em recém-nascidos a termo: aspectos da fase aguda e evolução
Noventa e quatro recém-nascidos com encefalopatia hipóxico-isquêmica (EHI), atendidos no Hospital das Clínicas de Ribeirão Preto desde 1982, foram avaliados evolutivamente na fase aguda e por período médio de 47 meses. De 43 casos com EHI 1,40 se recuperaram em 96 horas e 3 faleceram. Dos 40 com EHI...
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Published in | Arquivos de neuro-psiquiatria Vol. 55; no. 4; pp. 771 - 779 |
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Main Authors | , , |
Format | Journal Article |
Language | Portuguese |
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Academia Brasileira de Neurologia - ABNEURO
1997
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Abstract | Noventa e quatro recém-nascidos com encefalopatia hipóxico-isquêmica (EHI), atendidos no Hospital das Clínicas de Ribeirão Preto desde 1982, foram avaliados evolutivamente na fase aguda e por período médio de 47 meses. De 43 casos com EHI 1,40 se recuperaram em 96 horas e 3 faleceram. Dos 40 com EHI II, 37,5% se recuperaram até o sétimo dia e demais permaneceram com alterações. Os 11 casos com grau III faleceram até o segundo mês de vida. As crianças com EHI grau I não apresentaram seqüelas motoras. Do grupo com EHI grau II 34,5% apresentaram paralisia cerebral e 17,7% atraso neuromotor. 80% dos casos com sequela apresentaram exame neurológico anormal além do sétimo dia, na fase aguda da EHI. Epilepsia ocorreu em 17,5% dos casos com EHI grau II e somente no grupo com seqüelas motoras. Teste de QI não evidenciou diferença significativa entre os grupos com grau I, II sem seqüelas motoras e o grupo controle. Com esses dados os autores reafirmaram a importância prognostica da evolução da EHI na fase aguda. |
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AbstractList | Noventa e quatro recém-nascidos com encefalopatia hipóxico-isquêmica (EHI), atendidos no Hospital das Clínicas de Ribeirão Preto desde 1982, foram avaliados evolutivamente na fase aguda e por período médio de 47 meses. De 43 casos com EHI 1,40 se recuperaram em 96 horas e 3 faleceram. Dos 40 com EHI II, 37,5% se recuperaram até o sétimo dia e demais permaneceram com alterações. Os 11 casos com grau III faleceram até o segundo mês de vida. As crianças com EHI grau I não apresentaram seqüelas motoras. Do grupo com EHI grau II 34,5% apresentaram paralisia cerebral e 17,7% atraso neuromotor. 80% dos casos com sequela apresentaram exame neurológico anormal além do sétimo dia, na fase aguda da EHI. Epilepsia ocorreu em 17,5% dos casos com EHI grau II e somente no grupo com seqüelas motoras. Teste de QI não evidenciou diferença significativa entre os grupos com grau I, II sem seqüelas motoras e o grupo controle. Com esses dados os autores reafirmaram a importância prognostica da evolução da EHI na fase aguda. |
Author | Moura-Ribeiro, Maria Valeriana L. de Funayama, Carolina A. R. Gonçalves, Arthur Lopes |
AuthorAffiliation | Universidade de São Paulo Universidade Estadual de Campinas |
AuthorAffiliation_xml | – name: Universidade de São Paulo – name: Universidade Estadual de Campinas |
Author_xml | – sequence: 1 givenname: Carolina A. R. surname: Funayama fullname: Funayama, Carolina A. R. organization: Universidade de São Paulo – sequence: 2 givenname: Maria Valeriana L. de surname: Moura-Ribeiro fullname: Moura-Ribeiro, Maria Valeriana L. de organization: Universidade Estadual de Campinas – sequence: 3 givenname: Arthur Lopes surname: Gonçalves fullname: Gonçalves, Arthur Lopes organization: Universidade de São Paulo |
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DocumentTitleAlternate | Perinatal hypoxic-ischemic encephalopathy: acute period and outcome |
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Keywords | paralisia cerebral follow-up neonatal asphyxia risk factors seguimento cerebral palsy asfixia neonatal fatores de risco |
Language | Portuguese |
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References | Diament, AJ 1976 Levene, MI; Grindulis, H; Sands, C; Moore, JR 1986; 1 Van Kranen-Mastenbroek, VHDM; Folmer, KB; Kingma, H 1993; 35 Lefèvre, AB 1972 Michaelis, R; Shulte, FJ; Noite, R 1970; 76 Nelson, KB; Ellenberg, JH 1979; 64 Funayama, CAR; Moura-Ribeiro, MVL; Gonçalves, AL 1991; 67 Lombroso, CT 1983; 34 Saint-Anne Dargassies, S 1977 D'Souza, SW; Richards, B 1978; 53 Scher, MS; Aso, K; Begarly, ME; Hamid, MY; Steppe, DA; Painter, MJ 1993; 91 Terman, LM; Merrill, MA 1973 Zdanska-Brincken, M; Wolánski, N 1969; 11 Fenichel, GM; Webster, DL; Wong, WKT 1984; 41 Funayama, CAR 1990 Volpe, JJ 1995 Fenichel, GM 1983; 40 Sarnat, HB; Sarnat, MS 1976; 33 Gherpelli, JLD; Ferreira, H; Costa, HPF 1993; 51 Robertson, CM; Finer, N 1985; 27 Robertson, CM; Finer, N; Grace, MG 1989; 114 Bergamasco, B; Benna, P; Ferrero, P; Gavinelli, R 1984; 25 André, M; Vert, P; Debruille, CH 1978; 35 Apgar, V 1953; 32 Finer, N; Robertson, CM; Richards, RT; Pinnel, LE; Peters, KL 1981; 98 |
References_xml | – volume: 35 start-page: 23 year: 1978 end-page: 36 article-title: Diagnostic et evolution de la souffrance cerebrale chez les nouveau-nés ayant presents des signes d'hypoxie foetale: étude prospective publication-title: Arch Fr Ped contributor: fullname: André, M; Vert, P; Debruille, CH – volume: 76 start-page: 208 year: 1970 end-page: 213 article-title: Motor behaviour of small-for-gestational age newborn infants publication-title: J Pediatr contributor: fullname: Michaelis, R; Shulte, FJ; Noite, R – volume: 98 start-page: 112 year: 1981 end-page: 117 article-title: Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome publication-title: J Pediatr contributor: fullname: Finer, N; Robertson, CM; Richards, RT; Pinnel, LE; Peters, KL – volume: 33 start-page: 696 year: 1976 end-page: 705 article-title: Neonatal encephalopathy following fetal distress publication-title: Arch Neurol contributor: fullname: Sarnat, HB; Sarnat, MS – volume: 64 start-page: 225 year: 1979 end-page: 232 article-title: Neonatal signs as predictors of cerebral palsy publication-title: Pediatrics contributor: fullname: Nelson, KB; Ellenberg, JH – volume: 91 start-page: 128 year: 1993 end-page: 134 article-title: Electrographic seizures in preterm and full-term neonates: clinical correlates associated brain lesions, and risk for neurologic sequelae publication-title: Pediatrics contributor: fullname: Scher, MS; Aso, K; Begarly, ME; Hamid, MY; Steppe, DA; Painter, MJ – volume: 27 start-page: 437 year: 1985 end-page: 484 article-title: Term infants with hypoxic-ischemic encephalopathy: outcome at 3,5 years publication-title: Dev Med Child Neurol contributor: fullname: Robertson, CM; Finer, N – volume: 32 start-page: 260 year: 1953 end-page: 267 article-title: A proposal for a new method of evaluation of the newborn infant publication-title: Anesth Analg contributor: fullname: Apgar, V – volume: 11 start-page: 228 year: 1969 end-page: 241 article-title: A graph method for the evaluation of motor development in infants publication-title: Dev Med Child Neurol contributor: fullname: Zdanska-Brincken, M; Wolánski, N – year: 1976 publication-title: Evolução neurológica do lactente normal contributor: fullname: Diament, AJ – year: 1973 publication-title: Stanford-Binet Intelligence Scale (Form L-M) contributor: fullname: Terman, LM; Merrill, MA – volume: 41 start-page: 30 year: 1984 end-page: 34 article-title: Intracranial hemorrhage in the term newborn publication-title: Arch Neurol contributor: fullname: Fenichel, GM; Webster, DL; Wong, WKT – volume: 1 start-page: 67 year: 1986 end-page: 68 article-title: Comparation of two methods of predicting outcome in perinatal asphyxia publication-title: Lancet, contributor: fullname: Levene, MI; Grindulis, H; Sands, C; Moore, JR – volume: 34 start-page: 101 year: 1983 end-page: 113 article-title: Prognosis in neonatal seizures publication-title: Adv Neurol contributor: fullname: Lombroso, CT – volume: 114 start-page: 753 year: 1989 end-page: 760 article-title: School perfomance of survivors of neonatal encephalopathy associated with birth asphyxia at term publication-title: J Pediatr contributor: fullname: Robertson, CM; Finer, N; Grace, MG – year: 1990 publication-title: Encefalopatia hipóxico-isquêmica perinatal: aspectos epidemiológicos, neurológicos da fase aguda e evolutivos contributor: fullname: Funayama, CAR – year: 1977 publication-title: Desarollo neurológico del recien nacido de termino y prematuro contributor: fullname: Saint-Anne Dargassies, S – start-page: 314 year: 1995 end-page: 348 publication-title: Neurology of the newborn contributor: fullname: Volpe, JJ – volume: 40 start-page: 261 year: 1983 end-page: 266 article-title: Hypoxi/Ischemic encephalopathy in the newborn publication-title: Arch Neurol contributor: fullname: Fenichel, GM – volume: 53 start-page: 564 year: 1978 end-page: 569 article-title: Neurological sequelae in newborn babies after perinatal asphyxia publication-title: Arch Dis Child contributor: fullname: D'Souza, SW; Richards, B – volume: 67 start-page: 371 year: 1991 end-page: 374 article-title: Encefalopatia hipóxico-isquêmica perinatal: aspectos epidemiológicos publication-title: Pediatria contributor: fullname: Funayama, CAR; Moura-Ribeiro, MVL; Gonçalves, AL – year: 1972 publication-title: Exame neurológico evolutivo contributor: fullname: Lefèvre, AB – volume: 51 start-page: 50 year: 1993 end-page: 58 article-title: Neurological follow-up of small-for- gestational age newborn infants: a study of risk factors related to prognosis at one year of age publication-title: Arq Neuropsiquiatr contributor: fullname: Gherpelli, JLD; Ferreira, H; Costa, HPF – volume: 35 start-page: 516 year: 1993 end-page: 524 article-title: Postural behavior of term SGA and AGA newborn infants publication-title: Dev Med Child Neurol contributor: fullname: Van Kranen-Mastenbroek, VHDM; Folmer, KB; Kingma, H – volume: 25 start-page: 131 year: 1984 end-page: 136 article-title: Neonatal hypoxia and epileptic risk: a clinical prospective study publication-title: Epilepsia contributor: fullname: Bergamasco, B; 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