Preparation and Characterization of Composite Drug Membranes of Gelatin/Chitosan to Ocular

TB3; Composite drug membranes of gelatin/chitosan for therapy of glaucoma by trabeculectomy were prepared through solvent volatilization, using triamcinolone acetonide as a model drug. The membranes were characterized by FT- IR, X-RD and SEM. Their degradability and swelling ability and biocompatibi...

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Published in武汉理工大学学报(材料科学版)英 Vol. 20; no. z1; pp. 268 - 270
Main Authors GAO Yuxiang, YAN Yuhua, JIN Zhongqiu, ZHOU Xiong, SHANG Xumin
Format Journal Article
LanguageEnglish
Published Biomedical Materials and Engineering Center of Wuhan University of Technology,Wuhan 430070,China%Department of Ophthalmology,Wuhan General Hospital of Guangzhou Military Command Area,Wuhan 430070,China 01.12.2005
Subjects
chitosan
ocular implant
drug delivery
gelatin
glaucoma
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Summary:TB3; Composite drug membranes of gelatin/chitosan for therapy of glaucoma by trabeculectomy were prepared through solvent volatilization, using triamcinolone acetonide as a model drug. The membranes were characterized by FT- IR, X-RD and SEM. Their degradability and swelling ability and biocompatibility were studied. The results showed that biocompatibility , flexibility, swelling ability and degradability of the composite films were better than pure film of chitosan . The composite membrane containing 25% (w/w) of gelatin was best. The drug was loaded in film in crystallite. The rabbit eyes experiment after 8 weeks showed that the form of follicle was all right, and ophthalmototus maintain in the perfect level.
ISSN:1000-2413
1993-0437