Preparation and Characterization of Composite Drug Membranes of Gelatin/Chitosan to Ocular
TB3; Composite drug membranes of gelatin/chitosan for therapy of glaucoma by trabeculectomy were prepared through solvent volatilization, using triamcinolone acetonide as a model drug. The membranes were characterized by FT- IR, X-RD and SEM. Their degradability and swelling ability and biocompatibi...
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Published in | 武汉理工大学学报(材料科学版)英 Vol. 20; no. z1; pp. 268 - 270 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Biomedical Materials and Engineering Center of Wuhan University of Technology,Wuhan 430070,China%Department of Ophthalmology,Wuhan General Hospital of Guangzhou Military Command Area,Wuhan 430070,China
01.12.2005
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Subjects | |
Online Access | Get full text |
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Summary: | TB3; Composite drug membranes of gelatin/chitosan for therapy of glaucoma by trabeculectomy were prepared through solvent volatilization, using triamcinolone acetonide as a model drug. The membranes were characterized by FT- IR, X-RD and SEM. Their degradability and swelling ability and biocompatibility were studied. The results showed that biocompatibility , flexibility, swelling ability and degradability of the composite films were better than pure film of chitosan . The composite membrane containing 25% (w/w) of gelatin was best. The drug was loaded in film in crystallite. The rabbit eyes experiment after 8 weeks showed that the form of follicle was all right, and ophthalmototus maintain in the perfect level. |
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ISSN: | 1000-2413 1993-0437 |