Preparation and Drug-Release Property of Polycaprolactone(PCL)/Polyglycolic Acid(PGA)Composite Masterbatch with Drug of Tea Polyphenols(TPs)

• Published in: 东华大学学报（英文版） Vol. 40; no. 3; pp. 277 - 283
• Main Authors: WU Gaihong, LIU Shuqiang, YANG Yaru, PATOWAR Md Moinul Hossain, ROMEN Chakma, LI Jingjing, ZHANG Di, YANG Zhichao, LU Dongdong
• Format: Journal Article
• Language: English
• Published: Key Lab for Sport Shoes Upper Materials of Fujian Province,Fujian Huafeng New Material Co.,Ltd.,Putian 351164,China%College of Materials and Textile Engineering,Jiaxing University,Jiaxing 314001,China%Key Lab for Sport Shoes Upper Materials of Fujian Province,Fujian Huafeng New Material Co.,Ltd.,Putian 351164,China 01.06.2023; College of Textile Engineering,Taiyuan University of Technology,Taiyuan 030024,China%College of Textile Engineering,Taiyuan University of Technology,Taiyuan 030024,China
• Subjects: composite masterbatch; polycaprolactone(PCL); polyglycolic acid(PGA); tea polyphenol(TP); drug release
• ISSN: 1672-5220
• DOI: 10.19884/j.1672-5220.202207006

TS102.5; In order to effectively control the drug-release rate of medical textiles,biodegradable polycaprolactone(PCL)and polyglycolic acid(PGA)were blended at various mass ratios to prepare composite masterbatches for medical textiles.The surface morphology and the chemical structure of the masterbatches were analyzed.The crystallization,mass losses,strengths and drug-release rates of the composite masterbatches at different PCL/PGA mass ratios were explored.The results show that the degradation rate of the PGA carrier is obvious higher than that of the PCL carrier,and PCL,PGA and the tea polyphenol(TP)drug just physically mix without chemical reaction.During the degradation,the strength of the composite masterbatches gradually decreases.In addition,the drug-release rates of composite masterbatches at different mass ratios are different,and the more the PGA in the composite masterbatches,the faster the drug release of the composite masterbatches.The drug-release rate of the composite masterbatches can be controlled by adjusting the contents of PCL and PGA.