Concise Synthesis and Fertility-Promoting Activity of Thiamidol

O69; In order to make the synthetic route of Thiamidol more efficient and easier to scale up,a new method was developed.The compound 2,4-dihydroxyacetophenone was dissolved in ethyl acetate and brominated with cupric bromide.After bromination,the mixture was filtered to remove cuprous bromide.The ob...

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Published in东华大学学报（英文版） Vol. 40; no. 5; pp. 482 - 489
Main Authors ZHU Rouyu, GUO Lina, ZHU Jun, DIAO Hua, SHAO Zhiyu
Format Journal Article
LanguageEnglish
Published 31.10.2023
Subjects
synthetic route
sperm motility
Thiamidol
fertility
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Summary:O69; In order to make the synthetic route of Thiamidol more efficient and easier to scale up,a new method was developed.The compound 2,4-dihydroxyacetophenone was dissolved in ethyl acetate and brominated with cupric bromide.After bromination,the mixture was filtered to remove cuprous bromide.The obtained ethyl acetate solution containing 2-bromo-1-(2,4-dihydroxyphenyl)ethanone was directly reacted with(2-methylpropanoyl)thiourea to obtain the precipitate of Thiamidol hydrobromide.The precipitate was neutralized by deacidification and recrystallized to afford Thiamidol with high purity.In addition,in the screening of fertility-promoting substances,Thiamidol was found to be effective in protecting human sperm from motility loss in vitro.This suggests that it may have potential application in fertility protection and promotion.
ISSN:1672-5220
DOI:10.19884/j.1672-5220.202303001