GGA2在囊泡转运和相关疾病中作用的研究进展

• Published in: 中国病理生理杂志 Vol. 40; no. 3; pp. 543 - 550
• Main Authors: 陶逸豪, 拜尔娜·木太力甫, 祁正芳, 刘昶吾, 田园, 韩洋洋
• Format: Journal Article
• Language: Chinese
• Published: 新疆医科大学基础医学院生物学教研室,新疆 乌鲁木齐 830017%新疆医科大学基础医学院生物学教研室,新疆 乌鲁木齐 830017 01.03.2024; 西安交通大学医学部基础医学院人体解剖与组织胚胎学系,陕西 西安 710061; 新疆地方病分子生物学重点实验室,新疆 乌鲁木齐 830017
• Subjects: GGA2 protein; 囊泡转运; 癌症; Alzheimer disease; 阿尔茨海默病; vesicle transport; cancer; diabetes mellitus; GGA2蛋白; 糖尿病
• ISSN: 1000-4718
• DOI: 10.3969/j.issn.1000-4718.2024.03.019

R73%R742%R587.1%R329.2; Cellular dysfunction caused by vesicle transport is associated with a variety of diseases.The trans-Golgi network(TGN)to endosome transport is an important pathway of vesicle transport,and its defects leading to protein balance disorders has been linked to many diseases such as cancer,neurodegenerative diseases and diabetes mellitus.Gol-gi-associated gamma-adaptin ear-containing ADP-ribosylation factor-binding protein 2(GGA2)is a crucial protein in-volved in TGN-endosomal transport.It plays a significant role in the regulation of several diseases,including cancer,Al-zheimer disease,type 2 diabetes mellitus and cerebral ischemia,by mediating protein transport with important biological significance.This article provides an overview of the molecular structure of GGA2,its role in regulating clathrin-mediated protein transport between TGN and endosomes,and its potential implications for a variety of diseases.