Production of Ac for medical application from Th-metallic targets in Nb-shells irradiated with middle-energy protons

• Published in: New journal of chemistry Vol. 48; no. 18; pp. 8222 - 8232
• Main Authors: Ermolaev, Stanislav V, Vasiliev, Aleksandr N, Lapshina, Elena V, Kobtsev, Aleksandr A, Zhuikov, Boris L
• Format: Journal Article
• Language: English
• Published: 07.05.2024
• ISSN: 1144-0546; 1369-9261
• DOI: 10.1039/d3nj05778j

A method for high-scale 225 Ac-production for medical application from a massive metallic 232 Th-target irradiated with 160 MeV-protons is described. The target was made of a metallic Th disk of few mm thickness encapsulated in Nb shell using diffusion welding that provided effective target cooling under an intensive proton beam. Chemical processing started with selectively dissolving Nb and Th in mixtures of HF and HNO 3 of different concentrations. The further chemical treatment included two sequential extractions of Th( iv ) with di(2-ethylhexyl)orthophoshoric acid (HDEHP) and purification of Ac by extraction chromatography with DGA-, LN- and TRU-resins. The "end-to-start" technique, where the eluate of the column filled with one sorbent serves as the eluent for the column with next sorbent, was realized. The achieved total chemical yield of 225 Ac was 87% and radionuclidic purity was better than 99.8% (excepting 0.1-0.2% 227 Ac generated at the end of irradiation). The presented method can provide a hundred GBq of 225 Ac in one irradiation run. A method for large-scale production of prospective medical radionuclide 225 Ac including irradiation of a massive metallic 232 Th-target in Nb-shell with 160 MeV-protons and original procedure of highly purified 225 Ac isolation has been developed.