Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. alpha,beta-diaminopyrrolidinones
The electrophilic amination of a beta -aminolactam, itself derived from the conjugate addition of O,N- dibenzylhydroxylamine to a highly activated alpha,beta -unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of...
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Published in | Perkin 1 : an international journal of organic and bio-organic chemistry no. 22; pp. 3007 - 3012 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
15.11.2001
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Subjects | |
Online Access | Get more information |
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Summary: | The electrophilic amination of a beta -aminolactam, itself derived from the conjugate addition of O,N- dibenzylhydroxylamine to a highly activated alpha,beta -unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols. |
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ISSN: | 1472-7781 |
DOI: | 10.1039/b106783b |