Bioengineering considerations in the clinical trial of a bioartificial liver

A bioartificial liver that is undergoing clinical testing is described. The heart of the system is a hollow-fiber cartridge containing primary porcine hepatocytes that provide metabolic support to a patient with acute liver failure. The system is equipped with pressure and flow sensors for maintenan...

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Published inAnnals of biomedical engineering Vol. 28; no. SUPPL. 1; pp. S - 5
Main Authors Schaub, Richard Jr, Patzer, John F, Severyn, Donald, Winowich, Stephen, Kormos, Robert, Borovetz, Harvey
Format Journal Article
LanguageEnglish
Published 01.01.2000
Subjects
Biological membranes
Biological organs
Biomedical engineering
Blood
Blood vessels
Cells
Diseases
Hemodynamics
Metabolism
Patient treatment
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Summary:A bioartificial liver that is undergoing clinical testing is described. The heart of the system is a hollow-fiber cartridge containing primary porcine hepatocytes that provide metabolic support to a patient with acute liver failure. The system is equipped with pressure and flow sensors for maintenance of blood flow through the system further, it maintains blood gas content, pH and temperature at specified set points.
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ISSN:0090-6964