High resolution method for comparing defibrillation efficacy of experimental treatments in pigs

Accurate determination of defibrillation (D) strength requirements (DSR) in animal experiments requires fitting curves to conversion data. The resultant D probability curve (DPC) relates DSR to D probability. Conventional methods for determining DPCs use a single internal test shock (S) followed by...

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Published inProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society : San Diego, California, USA, October 28-31, 1993 Vol. 15; no. pt 2; p. 875
Main Authors Kenknight, Bruce H, Hahn, Stephen J, Heil, John E, Dahl, R Oger W, Lang, Douglas J
Format Journal Article
LanguageEnglish
Published 01.01.1993
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Summary:Accurate determination of defibrillation (D) strength requirements (DSR) in animal experiments requires fitting curves to conversion data. The resultant D probability curve (DPC) relates DSR to D probability. Conventional methods for determining DPCs use a single internal test shock (S) followed by a transthoracic rescue shock if needed. We hypothesized that giving multiple shocks at ) 5 s intervals (M) during a fibrillation episode would yield an improved technique in the pig model. To compare the S and M protocols, paired values (n identical with 48) of peak current at 50% D probability (150) were obtained in 23 pigs. The ratio (S/M) was 1.02 plus or minus 0.16. M yielded 150s that are not different than those obtained from S and decreased the time required to compared treatments by ) 30%.
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ISBN:0780313771
9780780313774