Characterization of the immunodeficiency of RIIIS/J mice. I. Association with the CD5 (Ly-1) B cell lineage

RIIIS/J mice produce low antibody responses to several polysaccharide Ag of bacterial origin. They have low levels of serum IgM and IgG3 and high levels of serum IgG2a and IgG2b. Low serum IgM and IgG3 have been attributed to a low frequency of CD5 (Ly-1) B cells, which play an important role in the...

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Published inThe Journal of immunology (1950) Vol. 142; no. 6; pp. 1813 - 1817
Main Authors Hiernaux, J R, Goidl, E A, Mcevoy, SJM, Stashak, P W, Baker, P J, Holmes, K L
Format Journal Article
LanguageEnglish
Published 01.01.1989
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Summary:RIIIS/J mice produce low antibody responses to several polysaccharide Ag of bacterial origin. They have low levels of serum IgM and IgG3 and high levels of serum IgG2a and IgG2b. Low serum IgM and IgG3 have been attributed to a low frequency of CD5 (Ly-1) B cells, which play an important role in the production of natural antibodies. These cells represent the CD5 (Ly-1) "sister population" of CD5 (Ly-1) B cells described by others. This suggests that characteristics usually associated with the CD5 (Ly-1) lineage are applicable only to the CD5 (Ly-1) super(+) Mac-1 super(+) IgM super(+) population, but not the related CD5 (Ly-1) super(-) Mac-1 super(+) IgM super(+) population. RIIIS/J mice should thus prove a valuable model to study the CD5 (Ly-1) B cell lineage.
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ISSN:0022-1767