Gene expression profiling by frequency distribution - a bioinformatic approach to characterizing tissue repair dynamics

A study was conducted to examine the frequency distribution of levels of gene expression to characterize the underlying dynamics of fracture healing. Experimental data obtained from RT-PCR differential display gels demonstrate distributions compatible with a power law for normal bone and healing bon...

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Bibliographic Details
Published inAnnals of biomedical engineering Vol. 28; no. SUPPL. 1; pp. S - 31
Main Authors McLead, Kenneth, Rubin, Clinton, Laramee, Craig
Format Journal Article
LanguageEnglish
Published 01.01.2000
Subjects
Biomechanics
Bone
Cells
Fracture fixation
Tissue
Ultrasonic applications
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Summary:A study was conducted to examine the frequency distribution of levels of gene expression to characterize the underlying dynamics of fracture healing. Experimental data obtained from RT-PCR differential display gels demonstrate distributions compatible with a power law for normal bone and healing bone (control), as well as healing bone accelerated by ultrasound treatment. It was also possible to identify a significant change in the distribution for fracture healing with ultrasound as compared to control.
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ISSN:0090-6964