Tunneling Nanotubes in Myeloid Cells: Perspectives for Health and Infectious Diseases

Tunneling nanotubes (TNTs) are cellular connections, which represent a novel route for cell-to-cell communication. Strong evidence points to a role for TNTs in the intercellular transfer of signals, molecules, organelles, and pathogens, involving them in many cellular functions. In myeloid cells (e....

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Bibliographic Details
Published inResults and problems in cell differentiation Vol. 73; p. 419
Main Authors Rey-Barroso, Javier, Dufrançais, Ophélie, Vérollet, Christel
Format Journal Article
LanguageEnglish
Published Germany 2024
Subjects
Animals
Cell Communication - physiology
Cell Membrane Structures
HIV Infections - immunology
HIV-1 - physiology
Humans
Myeloid Cells
Nanotubes
HIV-1
Pathogens
Myeloid cells
Tunneling nanotubes
Macrophages, osteoclasts
Innate immunity
Cell fusion
Multinucleated giant cells
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Summary:Tunneling nanotubes (TNTs) are cellular connections, which represent a novel route for cell-to-cell communication. Strong evidence points to a role for TNTs in the intercellular transfer of signals, molecules, organelles, and pathogens, involving them in many cellular functions. In myeloid cells (e.g., monocytes/macrophages, dendritic cells, and osteoclasts), intercellular communication via TNT contributes to their differentiation and immune functions, by favoring material and pathogen transfer, as well as cell fusion. This chapter addresses the complexity of the definition and characterization of TNTs in myeloid cells, the different processes involved in their formation, their existence in vivo, and finally their function(s) in health and infectious diseases, with the example of HIV-1 infection.
ISSN:0080-1844
DOI:10.1007/978-3-031-62036-2_17