Potential and application of abortive transcripts as a novel molecular marker of cancers

Abortive transcript (AT) is a 2-19 nt long non-coding RNA that is produced in the abortive initiation stage. Abortive initiation was found to be closely related to RNA polymerase through experiments. Therefore, the distribution of AT length and the scale of abortive initiation are correlated to the...

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Published inWorld journal of experimental medicine Vol. 14; no. 2; p. 92343
Main Authors Zhang, Tian-Miao, Zhu, Xiao-Nian, Qin, Shao-Wei, Guo, Xue-Feng, Xing, Xue-Kun, Zhao, Li-Feng, Tan, Sheng-Kui
Format Journal Article
LanguageEnglish
Published United States 20.06.2024
Subjects
Tumor marker
Abortive initiation
RNA polymerase
Transcription
Abortive transcript
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Summary:Abortive transcript (AT) is a 2-19 nt long non-coding RNA that is produced in the abortive initiation stage. Abortive initiation was found to be closely related to RNA polymerase through experiments. Therefore, the distribution of AT length and the scale of abortive initiation are correlated to the promoter, discriminator, and transcription initiation sequence, and can be affected by transcription elongation factors. AT plays an important role in the occurrence and development of various diseases. Here we summarize the discovery of AT, the factors responsible for AT formation, the detection methods and biological functions of AT, to provide new clues for finding potential targets in the early diagnosis and treatment of cancers.
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ISSN:2220-315X
2220-315X
DOI:10.5493/wjem.v14.i2.92343