Relationship between chlorpyrifos exposure level in pregnancy and neonatal anthropometric indices at birth

• Published in: Huan jing yu zhi ye yi xue = Journal of environmental & occupational medicine Vol. 38; no. 9; p. 930
• Main Authors: Zhang, Boya, Xu, Yurou, Zhang, Jiming, Guo, Jianqiu, Qi, Xiaojuan, Lyu, Shenliang, Chang, Xiuli, Wu, Chunhua, Zhou, Zhijun
• Format: Journal Article
• Language: Chinese
• Published: Shanghai Shanghai Municipal Center For Disease Control and Prevention 01.01.2021
• Subjects: Agricultural production; Anthropometry; Birth weight; Body length; Body mass; Body mass index; Body measurements; Body size; Chlorpyrifos; Creatinine; Demographic variables; Exposure; Gas chromatography; Gender aspects; Generalized linear models; Health risks; Mass spectrometry; Mass spectroscopy; Metabolites; Neonates; Organophosphorus pesticides; Pesticides; Ponderal index; Pregnancy; Prenatal experience; Prenatal exposure; Sex differences; Statistical models; Trichloro-2-pyridinol; Weight
• DOI: 10.13213/j.cnki.jeom.2021.21131
• ISSN: 2095-9982

[Background] The organophosphorus pesticide chlorpyrifos (CPF) is widely used in agricultural production, and the resulting environmental pollution and health risk are serious concerns. [Objective] This study aims to investigate the relationship between CPF exposure level in pregnancy and anthropometric indices of newborns at birth. [Methods] A total of 1 100 mother-child pairs in Jiangsu Sheyang Mini Birth Cohort Study were enrolled as study subjects. Length, head circumference, and birth weight of the newborns were measured by professional midwives, and body mass index (BMI) and ponderal index (PI) were calculated. A questionnaire survey was conducted to collected maternal socio-demographic characteristics and pregnancy variables. Spot urine samples were collected during pregnancy. Maternal urinary concentrations of 3, 5, 6-trichloro-2-pyridinol (TCPy, a specific metabolite of CPF) were measured by gas chromatography tandem mass spectrometry. Generalized linear models were used to evaluate the relationships