Relationship between chlorpyrifos exposure level in pregnancy and neonatal anthropometric indices at birth

[Background] The organophosphorus pesticide chlorpyrifos (CPF) is widely used in agricultural production, and the resulting environmental pollution and health risk are serious concerns. [Objective] This study aims to investigate the relationship between CPF exposure level in pregnancy and anthropome...

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Published inHuan jing yu zhi ye yi xue = Journal of environmental & occupational medicine Vol. 38; no. 9; p. 930
Main Authors Zhang, Boya, Xu, Yurou, Zhang, Jiming, Guo, Jianqiu, Qi, Xiaojuan, Lyu, Shenliang, Chang, Xiuli, Wu, Chunhua, Zhou, Zhijun
Format Journal Article
LanguageChinese
Published Shanghai Shanghai Municipal Center For Disease Control and Prevention 01.01.2021
Subjects
Agricultural production
Anthropometry
Birth weight
Body length
Body mass
Body mass index
Body measurements
Body size
Chlorpyrifos
Creatinine
Demographic variables
Exposure
Gas chromatography
Gender aspects
Generalized linear models
Health risks
Mass spectrometry
Mass spectroscopy
Metabolites
Neonates
Organophosphorus pesticides
Pesticides
Ponderal index
Pregnancy
Prenatal experience
Prenatal exposure
Sex differences
Statistical models
Trichloro-2-pyridinol
Weight
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Summary:[Background] The organophosphorus pesticide chlorpyrifos (CPF) is widely used in agricultural production, and the resulting environmental pollution and health risk are serious concerns. [Objective] This study aims to investigate the relationship between CPF exposure level in pregnancy and anthropometric indices of newborns at birth. [Methods] A total of 1 100 mother-child pairs in Jiangsu Sheyang Mini Birth Cohort Study were enrolled as study subjects. Length, head circumference, and birth weight of the newborns were measured by professional midwives, and body mass index (BMI) and ponderal index (PI) were calculated. A questionnaire survey was conducted to collected maternal socio-demographic characteristics and pregnancy variables. Spot urine samples were collected during pregnancy. Maternal urinary concentrations of 3, 5, 6-trichloro-2-pyridinol (TCPy, a specific metabolite of CPF) were measured by gas chromatography tandem mass spectrometry. Generalized linear models were used to evaluate the relationships
ISSN:2095-9982
DOI:10.13213/j.cnki.jeom.2021.21131