Treatment of an elderly patient with acute myelocytic leukemia transformed from myelodysplastic syndrome with decitabine in ultra-low dosage combining with transfusion of autologous cytokineinduced killer cells: a case report and review of literature
Objective To investigate the efficacy and safety of decitabine in ultra-low dose combining with autologous cytokine-induced killer (CIK) cells for treatment of elderly patients with acute myelocytic leukemia (AML) transformed from myelodysplastic syndrome (MDS). Methods An 83-year-old patient with i...
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Published in | Jie fang jun yi xue za zhi Vol. 39; no. 4; p. 315 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
Beijing
People's Military Medical Press
01.04.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Objective To investigate the efficacy and safety of decitabine in ultra-low dose combining with autologous cytokine-induced killer (CIK) cells for treatment of elderly patients with acute myelocytic leukemia (AML) transformed from myelodysplastic syndrome (MDS). Methods An 83-year-old patient with initial diagnosis of MDS-RA was treated with amifostine combined with erythropoietin (EPO), and hemogram was improved nearly to normal lasting about three and a half years. Then the patient's morbidity transformed to chronic myelomonocytic leukemia (AML-M4) two months later. Then the patient was treated with an ultra-low dose of decitabine combining with autologous CIK cells. The detailed treatment included decitabine 10mg, d1-5, and CIK cells transfusion (2×109-8×109 each time) d14; rhIL-2 2mU d15-19. 28-day treatment was accounted as one treatment course. Side effects, changes in hemogram, signs of recuperation and duration of survival were systematically observed. Further, the literature concerning decitabine for |
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ISSN: | 0577-7402 |
DOI: | 10.11855/j.issn.0577-7402.2014.04.13 |