AIBN for Ru-catalyzed meta-CAr–H alkylation

The meta-CAr–H alkylation of arenes with radicals produced from AIBN in the presence of a RuCl3 catalyst is presented. This development not only confirmed that ruthenium-catalyzed meta-CAr–H bond functionalization is a radical process, but also provided an efficient and practical strategy for the pr...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 7; no. 17; pp. 2474 - 2479
Main Authors Yang, Suling, Yan, Bingxu, Zhong, Lei, Jia, Chunqi, Yao, Dan, Yang, Chunli, Sun, Kai, Li, Gang
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 07.09.2020
Subjects
Alkylation
Aromatic compounds
Biological activity
Catalysts
Functional materials
Hydrogen bonds
Organic chemistry
Ruthenium
Ruthenium trichloride
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Summary:The meta-CAr–H alkylation of arenes with radicals produced from AIBN in the presence of a RuCl3 catalyst is presented. This development not only confirmed that ruthenium-catalyzed meta-CAr–H bond functionalization is a radical process, but also provided an efficient and practical strategy for the preparation of aromatic compounds containing a nitrile group, which are prevalent in a diverse range of biologically active molecules and other functional materials.
ISSN:2052-4110
2052-4110
DOI:10.1039/d0qo00703j