Level of Tumor Necrosis Factor Alpha in Elderly Patients with Periodontitis and Diabetes Mellitus

Periodontal diseases, such as periodontitis, have risk factors in common with other systemic and chronic inflammatory disorders. One inflammatory mediator that plays a role in the proinflammatory process is tumor necrosis factor a (TNF-a). With age, the body's inflammatory responses change, and...

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Published inJournal of International Dental & Medical Research Vol. 13; no. 4; pp. 1461 - 1466
Main Authors Kurniati, Fonny, Masulili, Sri C Lelyati, Haerani, Natalina, Tadjoedin, Fatimah Maria, Harsas, Nadhia Anindhita, Soedarsono, Nurtami, Wulandari, Pitu
Format Journal Article
LanguageEnglish
Published Diyarbakir Ectodermal Dysplasia Group - Turkey 01.01.2020
Subjects
Chronic illnesses
Diabetes mellitus
Gum disease
Inflammatory diseases
Insulin resistance
Necrosis
Older people
Periodontal diseases
Periodontitis
Risk factors
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Periodontal diseases, such as periodontitis, have risk factors in common with other systemic and chronic inflammatory disorders. One inflammatory mediator that plays a role in the proinflammatory process is tumor necrosis factor a (TNF-a). With age, the body's inflammatory responses change, and this is one reason why periodontitis is common among elderly patients. We compared TNF-a levels of 33 elderly patients with periodontitis who did not have diabetes with those of 18 elderly patients with both periodontitis and diabetes mellitus. Patients gingival crevicular fluid (GCF) was taken from sites with pocket depths of 5 to 6 mm, and their TNF-a levels were measured. Clinical data (pocket depth, bleeding index, and clinical attachment loss) and GCF samples were collected. Patients with diabetes had significantly higher Oral Health Information Suite indexes (3.1 ± 1.25) than did those without diabetes (2.17 ± 1.29; p < 0.05). Patients with diabetes had significantly higher TNF-a levels (5.04 ± 0.48) than did those without diabetes (4.67 ± 0.76; p < 0.05). Thus, the level of TNF-a is significantly higher in patients with diabetes than in those without.Clinical article (J Int Dent Med Res 2020; 13(4): 1461-1466) I
ISSN:1309-100X
1309-100X