Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion m...

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Bibliographic Details
Published inbioRxiv
Main Authors Khan, Haaris S, Nair, Vidhya, Ruhl, Cody R, Alvarez-Arguedas, Samuel, Galvan Rendiz, Jorge L, Franco, Luis H, Huang, Linzhang, Shaul, Philip, Mitchell, Ron B, Shiloh, Michael U
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.10.2019
Subjects
M cells
Mucosa
Mycobacterium tuberculosis
Respiratory tract
Scavenger receptors
Secretion
Tuberculosis
Virulence factors
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Summary:Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.
DOI:10.1101/807222