SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER

At the present time, immunosuppressive role of extracellular adenosine in carcinogenesis is actively investigated. Colorectal cancer is one of the most common types of malignant neoplasms in Russiaand worldwide, but the role of mediators of adenosine-dependent immunosuppression, such as CD39 (that h...

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Published inMedit͡s︡inskai͡a︡ immunologii͡a Vol. 19; no. 1; p. 89
Main Authors Zhulai, G A, Oleinik, E K, Churov, A V, Romanov, A A, Kravchenko, P N, Оleinik, V M
Format Journal Article
LanguageRussian
Published Saint Petersburg Russian Association of Allerologists and Clinical Immuniologists, St. Petersburg Branch 01.01.2017
Subjects
Adenosine
Carcinogenesis
CD25 antigen
CD4 antigen
CD73 antigen
Cell activation
Colorectal cancer
Colorectal carcinoma
Ectonucleotidase
Gene expression
Immunosuppression
Leukocytes
Lymphocytes T
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Summary:At the present time, immunosuppressive role of extracellular adenosine in carcinogenesis is actively investigated. Colorectal cancer is one of the most common types of malignant neoplasms in Russiaand worldwide, but the role of mediators of adenosine-dependent immunosuppression, such as CD39 (that hydrolyze ATP to adenosine), CD73, A2AR, is not yet clear in patients with colorectal cancer. The levels of specific mRNAs for A2AR, ectonucleotidase CD39, and CD73 genes were assayed in white blood cells of the patients with colorectal cancer. The results have shown that the CD39 mRNA content is increased in the patients with colorectal cancer in the course of the disease progression. Meanwhile, no significant difference for CD73 gene expression was found between the patients and healthy donors. Moreover, an increase in A2AR mRNA expression was noted for the patients with advanced colorectal cancer, thus presuming potential activation of adenosine-A2AR-mediated immunosuppressive mechanism. Furthermore, the CD39 expression on T cells was elevated in parallel to the cancer progression. The most significant changes in CD39 expression were observed for both T helper and Treg cell populations at the late stages of colorectal cancer. Similarly, a direct correlation was revealed between CD39 expression on CD4+CD25+CD127lo/-Treg cells, and changes of A2AR mRNA levels in leukocytes from the cancer patients.
ISSN:1563-0625
2313-741X
DOI:10.15789/1563-0625-2017-1-89-94