Coumarins and Chromones : A Remarkable Scaffolds for Anti-inflammatory Activity

The major anti-inflammatory targets include enzymes, cyclooxygenase (COX-1 and COX-2), 5lipooxygenase (5-LOX), inducible nitric oxide synthase (iNOS), inosine monophosphate dehydrogenase; cytokines and cytokine receptors, tumor necrosis factor (TNF)-a and TNF-RII, interleukin (IL)-1b and IL-1RA, IL-...

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Bibliographic Details
Published inJournal of pharmaceutical sciences and research Vol. 9; no. 9; p. 1483
Main Authors Bhargavi, Vijaya M, Shashikala, P, Sumakanth, M
Format Journal Article
LanguageEnglish
Published Cuddalore Journal of Pharmaceutical Sciences and Research 01.09.2017
Subjects
Chemistry
Enzymes
Inflammation
Natural products
Pharmaceutical sciences
Phenols
Rheumatoid arthritis
Rodents
Sodium
Sulfuric acid
Tumor necrosis factor-TNF
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Summary:The major anti-inflammatory targets include enzymes, cyclooxygenase (COX-1 and COX-2), 5lipooxygenase (5-LOX), inducible nitric oxide synthase (iNOS), inosine monophosphate dehydrogenase; cytokines and cytokine receptors, tumor necrosis factor (TNF)-a and TNF-RII, interleukin (IL)-1b and IL-1RA, IL-2 and IL-2R, interferon (IFN)-a2, IFN-b1, and IFN-g [4,5]. Due to non-reusability of these homogeneous catalysts different solid acid catalysts such as amberlyst ion-exchange resins, zeolites, montmorillonite K-10, polyaniline sulfate salt, heteropoly acids, nafion resin/silica nanocomposites and nano-crystalline sulfated-zirconia have been studied for the synthesis of coumarin derivatives. The in vitro antioxidant activity of the synthesized compounds was evaluated using two different antioxidant assays (radical scavenging ability of DPPH stable free radical and inhibition of lipid peroxidation induced by the thermal free radical AAPH). [...]the ability of the compounds to inhibit soybean lipoxygenase was determined as an indication of potential anti-inflammatory activity. The nuclear translocation of NF-kB and the phosphorylation level of JNK and p38 MAPK pathways were also inhibited by IMM-H004 in LPS-treated BV2 microglia. [...]IMM-H004 also was a strong selective OH . scavenger whose effect was similar with vitamin C. Overall, the findings suggested that IMM-H004 might be a promising therapeutic agent for alleviating the progress of neurodegenerative diseases associated with microglia activation.
ISSN:0975-1459