Characteristics and mechanism of secondary liver injury in pigs with traumatic hemorrhagic shock in dry heat environment

• Published in: Jie fang jun yi xue za zhi Vol. 46; no. 3; p. 245
• Main Authors: WU, Bin, YOU, Yun, Cai-Fu, SHEN, XIA, Liang, Xin-Yue, YANG, Hui-Wen, LI, Jiang-Wei, LIU, Yong-Hua, DAI
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 28.03.2021
• Subjects: Heat; Hemorrhagic shock; Humidity; Liver; Trauma
• ISSN: 0577-7402
• DOI: 10.11855/j.issn.0577-7402.2021.03.05

Objective　To document the dynamics of secondary liver injury in pigs with traumatic hemorrhagic shock (THS) induced by simulated desert dry heat environment and to explore its possible mechanism. Methods　Sixty male Landrace piglets were randomly divided into three groups: Dry heat trauma hemorrhagic shock group (DHS group, n=20), dry heat trauma hemorrhagic shock sham operation group (DHC group, n=20), normal temperature trauma hemorrhagic shock group (NTS group, n=20). DHS group and DHC group were exposed to a dry and hot environment [temperature (40.5±0.5) ℃, humidity 10%±2%]; while NTS group were exposed to normal temperature environment [temperature (25.0±0.5) ℃, humidity 35%±5%] for 3 h. Then the model of blood pressure controlled hemorrhagic shock was established. Animals were euthanized at 0 min (T0), 50 min (T1), 100 min (T2) or 150 min (T3) after the successful establishment of the hemorrhagic shock model, blood and live tissue were collected. The pathological changes of liver tissue were observed by