Oral Squamous Cell Carcinoma Positive for HPV Genotypes 16 and 18: A Retrospective Clinicopathologic Study in Yogyakarta, Indonesia

To evaluate the strength of associations between presence of HPV and the clinicopathologic features, odds ratios (ORs) and 95% confidence interval (CIs) were calculated using binary logistic regression analysis. Binary logistic regression analysis showed no statistically significant relation between...

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Bibliographic Details
Published inJournal of International Dental & Medical Research Vol. 11; no. 3; pp. 866 - 871
Main Authors Gracia, Isadora, Irianiwati, Utoro, Totok, Supriatno, Astuti, Indwiani, Heriyanto, Didik Setyo, Pramono, Dibyo
Format Journal Article
LanguageEnglish
Published Diyarbakir Ectodermal Dysplasia Group - Turkey 01.09.2018
Subjects
Age
Cancer
Deoxyribonucleic acid
DNA
Epidemiology
Genotype & phenotype
Genotypes
Health risk assessment
Human papillomavirus
Infections
Oral cancer
Oral squamous cell carcinoma
Regression analysis
Sex differences
Sexual behavior
Squamous cell carcinoma
Statistical analysis
Studies
Tongue
Asia
China
India
Indonesia
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Summary:To evaluate the strength of associations between presence of HPV and the clinicopathologic features, odds ratios (ORs) and 95% confidence interval (CIs) were calculated using binary logistic regression analysis. Binary logistic regression analysis showed no statistically significant relation between HPV infection status with gender, age, anatomical site, or histopathologic features (P>0.05) The distribution of HPV genotypes is summarized in Table 3. The present results for age and anatomical site are similar to those of previous studies conducted in other Asian countries; these studies reported that patients with OSCC fell in the age range of 51-55 years and that the tongue is the most common anatomical site for oral cancer.12 A report from a cancer hospital in Jakarta, Indonesia (2014) showed that tongue cancer is more prevalent in males than in females; tongue cancer is also more prevalent in the age group of 30-40 years than in other age groups.13 The prevalence of HPV-positive OSCC varies and is influenced by several factors, including geographic region, sample types, and HPV detection methods. Twenty-four cases were undetermined HPV genotypes. [...]future investigations are required to determine HPV genotypes using sequencing methods.
ISSN:1309-100X
1309-100X