Changes of metabolism in animals due to conditions of a purulent wound process while using photomineralisation as dressing tools

• Published in: Eurasian journal of biosciences Vol. 13; no. 2; pp. 763 - 767
• Main Authors: Krut, U A, Oleynikova, I I, Radchenko, A I, Kuzubova, E V
• Format: Journal Article
• Language: English
• Published: Izmir Foundation for Environmental Protection and Research, Çevre Koruma ve Araştırma Vakfı (ÇEVKOR) 01.08.2019
• Subjects: Alanine; Alanine transaminase; Amino acids; Antibiotics; Antimicrobial agents; Aspartate aminotransferase; Blood; Creatine; Creatinine; Deamination; Dephosphorylation; Laboratory animals; Metabolism; Microorganisms; Permeability; Pharmacy; Phosphocreatine; Proteins; Sorbents; Tricarboxylic acid cycle; Urea; Wound healing
• ISSN: 1307-9867

Annotation: the wound process is difficult, multicomponent and has its own a phase of character. Recently, there has been an active search for new products for the treatment and prevention of purulent wounds. The effect of sorbents on the process of wound healing is being studied. The impact of the damaging factor causes the development of inflammation, which leads to immediate biochemical changes. During primary alteration, cells are destroyed and their contents are released, the permeability of the vascular wall increases, and individual blood components can be easily transported to the external environment. Previously, a decrease in the concentration of total protein in the blood has already been noted. At the first stage of the wound process, one part of the protein is transferred to the exudate, and the other goes to decay to amino acids. In terms of energy disbalance amino acids enter into deamination and transamination reactions, as indicated by the high activity of alanine aminotransferase and aspartate aminotransferase as well as increased concentration of urea. The products of amino acid breakdown enter the Krebs cycle for subsequent energy production, which is necessary for further regeneration processes. Violations of the integrity of muscle tissue leads to the fact that the concentration of creatinine in the blood increases. Creatine phosphate due to the destruction of muscle fiber does not mobilize the generation of ATP, but reacts to non-enzymatic dephosphorylation with the formation of creatine anhydride - creatinine.