Protective Role of Basella rubra Against Bifenthrin and Lambda-Cyhalothrin Induced Thyro-Pancreatic Histopathology in Mice

• Published in: Fluoride Vol. 57; no. 2; pp. 1 - 10
• Main Authors: Ameer, Iqra, Ahmad, Syeda Nadia, Ahmad, Khawaja Raees, Kanwal, Muhammad Ali, Haider, Arifa, Suleman, Sadia, Inayat, Iram
• Format: Journal Article
• Language: English
• Published: Dunedin International Society for Fluoride Research, Inc 01.01.2024
• Subjects: Acids; Albinism; Animals; Blood vessels; Follicles; Hyperplasia; Insecticides; Pancreas; Spinach; Thyroid gland; Toxicity
• ISSN: 0015-4725; 2253-4083

This study was designed to explore the ameliorating effects of Basella rubra fruit extract against thyro-pancreatic histopathologies in lambda cyhalothrin and bifenthrin treated mice. Method: Thirty mature male albino mice were divided into 6 groups as follows: (i) and (ii) Vehicle control group/VC and Basella rubra/Br group (0.1mL corn oil and 0.1mL Basella rubra extract, respectively, for days 1-2; (iii) and (iv) Lambda-cyhalothrin (Lct) and Bifenthrin (Bf) groups (5mg/kg Lct and Bf solution in 0.1mL corn oil, respectively, for days 1-2); (v) LctBr and BfBr groups (5mg/kg lambda-cyhalothrin and bifenthrin in 0.1mL corn oil, respectively, for days 1-2 and 0.1mL of Basella rubra solution on days 4-6); For histological study, pancreas and thyroid were excised from all animals on day 7. Results: Let and Bf exposure was found to cause acinus focal degeneration, islets hypertrophy and hyperplasia in pancreas, ruptured follicles, thyroglobulin depletion and abnormally enlarged follicles in thyroid gland. The micrometric outcomes revealed that relative area occupied by endocrine cells and their relative abundance was reduced in Let and Bf (51.98±1.55 ; 61.46±1.32) groups compared to VC (88.87±2.86). Relative area occupied by endocrine cells per unit area was increased in Lct & Bf (51.98±1.55 ; 61.46±1.32) and increased in Br group (114.0±2.70) in than VC (88.87±2.86). In thyroid gland mean number follicular and C-cells were increased in Lct (229.64±9.82 ; 209.60±9.72) decreased (59.7±2.7 ; 80.4±4.2) in Bf group comparative to VC (97.80±3.70 ; 106.45±3.36). Conclusions: Both of the glands were equally and highly affected by these pyrethroids. All these deleterious effects of Let and Bf were markedly reversed in LctBr and BfBr groups. Use of Basella rubra showed a remarkable amelioration in Let and Bf treated groups. Basella rubra fruit extract showed rehabilitative potential against the histopathological signs of Let and Bf in male mice.Purpose: Insert text here.