Comparative study of the effects of rhKGF, CBLB502 and WR2721 on radiation-induced oral mucositis

• Published in: Jie fang jun yi xue za zhi Vol. 40; no. 5; p. 420
• Main Authors: YANG, Chao, Li-mei, WANG, CUI, Yu, Tie-zhu, XU, Zhi-wei, ZHAO, Zhong-tang, LI, Jun-ke, WANG, Ya-jun, SHAN, Xiao-lan, LIU, Hong-wei, TANG, Yu-wen, CONG
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.01.2015
• Subjects: Comparative studies
• ISSN: 0577-7402
• DOI: 10.11855/j.issn.0577-7402.2015.05.19

Objective　To compare the protective effect of rhKGF, CBLB502 and WR2721 on radiation-induced oral mucositis (ROM). Methods　Fifty male 6-8-week-old C57BL/6J mice were randomly divided into normal group, irradiation control group, rhKGF group, CBLB502 group, and WR2721 group (n=10 each). The 30-day survival rate and change in body weight of mice that had received 17Gy irradiation of head and neck area were recorded. In another group of 20 mice, 1% toluidine blue staining and HE staining were used to observe oral ulcers and pathological changes in the tongue tissue. The proliferation of keratinocyte cells was assessed by Ki-67 immunohistochemistry. Results　Compared with the irradiation control group, administration of rhKGF and WR2721 could significantly improve the 30-day survival rate, accelerate the recovery of body weight, and promote the proliferation of keratinized epithelial cells of mice after irradiation, without inducing obvious oral mucositis. However, There was no significant difference between CBLB5