Clinical observation of chemotherapy combined with autologous cytokine-induced killer cells and dendritic cells for advanced gastric cancer

Objective　To evaluate the clinical effects of chemotherapy combined with cytokine-induced killer (CIK) cells and dendritic cells (DC) on advanced gastric cancer. Methods　Seventy-two cases with advanced gastric cancer (stage Ⅳ) treated in 309 Hospital of PLA from Jan. 2011 to Jan. 2013 were randomly...

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Bibliographic Details
Published inJie fang jun yi xue za zhi Vol. 40; no. 6; p. 475
Main Authors LV, Gang, Qing-jun, ZHANG, Yu-qi, SHI, Zhi-yu, CAO
Format Journal Article
LanguageChinese
Published Beijing People's Military Medical Press 01.06.2015
Subjects
Chemotherapy
Cytokines
Dendritic cells
Gastric cancer
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Summary:Objective　To evaluate the clinical effects of chemotherapy combined with cytokine-induced killer (CIK) cells and dendritic cells (DC) on advanced gastric cancer. Methods　Seventy-two cases with advanced gastric cancer (stage Ⅳ) treated in 309 Hospital of PLA from Jan. 2011 to Jan. 2013 were randomly divided into chemotherapy group and combined therapeutic group. Chemotherapy group consisted of 35 cases, received 6 to 10 cycles of chemotherapy with the protocol of FOLFOX 4. Combined therapeutic group consisted of 37 cases, beside receiving the same chemotherapeutical protocol, they were given autologous CIK cells combined with subcutaneous injection of DC near inguinal and axillary lymph nodes. The changes in tumor burden, cellular immune responses (CD3+, CD4+, CD8+, CD3+CD56+, CD3–CD56+ and CD4+/CD8+) and the Karnofsky's grade were determined, and the 2-year survival rate of both groups was recorded. Results　All patients were followed up for 9~30 months (average 22 months). The disease control rate (DCR) was s
ISSN:0577-7402
DOI:10.11855/j.issn.0577-7402.2015.06.11