Short- and long- term curative efficacy of minimally invasive radical surgery and its effects on immune function and HIF-1α expression in patients with advanced gastric cancer

• Published in: Jie fang jun yi xue za zhi Vol. 43; no. 8; p. 694
• Main Authors: Hua-zhou, ZHAO, WANG, Ting, AN, Dan, Cai-xia, ZHANG, Xiao-chen, QIU, Jian-feng, WENG, Zhi-yu, CAO, Jian-miao HE, YANG, Bo
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.01.2018
• Subjects: Gastric cancer; Laparoscopy; Surgery
• ISSN: 0577-7402
• DOI: 10.11855/j.issn.0577-7402.2018.08.13

Objective　To observe the short- and long-term efficacy of minimally invasive radical surgery and its effect on immune function and hypoxia inducible factor-1α (HIF-1α) expression in patients with advanced gastric cancer, and provide a reference for clinical treatment of gastric cancer. Methods　A total of 90 patients with gastric cancer, admitted from Feb. 2010 to Mar. 2012, were enrolled in present study. Of the 90 patients, 48 underwent minimally invasive radical surgery (laparoscopic assisted radical surgery, laparoscopic group), and 42 underwent routine laparotomy (laparotomy group). The short-term efficacy included various clinical indexes (intraoperative bleeding, liquid diet time, exhaust time, operating time, hospital stay, lymph nodes), the incidence of postoperative complications and the immune function indexes (C3, C4, IgG, IgA, IgM) and the levels of C-reaction protein (CRP) and HIF-1α in serum. The long-term efficacy included five-year survival rate. Results　No perioperative death occurred in the