Hifα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing

• Published in: Science (American Association for the Advancement of Science) Vol. 292; no. 5516; pp. 464 - 468
• Main Authors: IVAN, Mircea, KONDO, Keiichi, YANG, Haifeng, KIM, William, VALIANDO, Jennifer, OHH, Michael, SALIC, Adrian, ASARA, John M, LANE, William S, KAELIN, William G
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 20.04.2001
• Subjects: Biological and medical sciences; Medical sciences; Neurology; Vascular diseases and vascular malformations of the nervous system; Human; Nervous system diseases; Oxygen; Phacomatosis; Targeting; Hydroxylation; Cardiovascular disease; Molecular interaction; Gene expression; Genetic disease; Vascular disease; Eye disease; Central nervous system disease; Hypoxia; Transcription factor; Von Hippel Lindau disease; Tumor suppressor gene
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1059817