A Novel Amorphous Delivery System to the Skin for Poorly Soluble Actives

In the case of volatile solvents such as alcohol, the solubility of the active decreases with application time, because of the fast evaporation of the alcohol, leading to precipitation of the active on the skin in the form of large crystals that have low penetration through the skin. At 1/500th the...

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Bibliographic Details
Published inPharmaceutical Technology Vol. 42; no. 6; pp. 25 - 27
Main Authors Müller, Rainer H, Herziger, Birthe, Monsuur, Fred, Pyo, Sung Min
Format Trade Publication Article
LanguageEnglish
Published Monmouth Junction MultiMedia Healthcare Inc 02.06.2018
Subjects
Alcohol
Cosmetics
Nanocrystals
Nanoparticles
Polyethylene glycol
Regulation
Skin
Solvents
United States > US
Germany
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Summary:In the case of volatile solvents such as alcohol, the solubility of the active decreases with application time, because of the fast evaporation of the alcohol, leading to precipitation of the active on the skin in the form of large crystals that have low penetration through the skin. At 1/500th the concentration of rutin dissolved from nanocrystals, a two-fold increase in sun protection factor (SPF) was observed in a human study with irradiated volunteers (4). According to the EU cosmetic regulation (6), for example, nanoparticulate ingredients must be declared, such as the case of titanium dioxide used in sunscreens. Because smartPearls are microparticles, no "nano" declaration is necessary for the final product.
ISSN:1543-2521
2150-7376