Lifecycle Cost Analysis for Single-Use Systems

The decision to use single-use systems for manufacturing pharmaceuticals hinges on many factors, but the major driving force is a desire to save cost and time. Although there is no doubt that single-use systems reduce capital costs, this analysis shows that in many cases lifecycle costs increase. Th...

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Bibliographic Details
Published inBiopharm International p. 30
Main Authors Barnoon, Barak I, Bader, Bob
Format Trade Publication Article
LanguageEnglish
Published Monmouth Junction MultiMedia Healthcare Inc 01.11.2008
Subjects
Automation
Capital costs
Case studies
Cost control
Design
Economics
Fermentation
HVAC
Manufacturing
Net present value
Operating costs
Replacement costs
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Summary:The decision to use single-use systems for manufacturing pharmaceuticals hinges on many factors, but the major driving force is a desire to save cost and time. Although there is no doubt that single-use systems reduce capital costs, this analysis shows that in many cases lifecycle costs increase. This article describes a methodology used during concept design to evaluate lifecycle costs of single-use systems. The methodology is implemented in a case study to determine the optimum mix of stainless-steel and single-use systems for a new biopharmaceutical manufacturing facility. Lifecycle costs, expressed as net present value (NPV), are evaluated for typical bioprocess applications including fermentation, recovery, purification, media and buffer prep, and buffer storage. [PUBLICATION ABSTRACT]
ISSN:1542-166X
1939-1862