Highly Efficient Olefin-Metathesis Catalysts

The newly developed Piers' first-generation catalysts and Piers' second-generation catalysts are highly efficient for several olefin-metathesis processes, including ethenolysis and ring-closing metathesis. The high proficiency of these catalysts is attributed to the unique 4-coordinate, 14...

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Bibliographic Details
Published inPharmaceutical Technology p. S18
Main Authors Bei, Xiaohong, Allen, Daryl P, Pederson, Richard L
Format Trade Publication Article
LanguageEnglish
Published Monmouth Junction MultiMedia Healthcare Inc 01.09.2008
Subjects
Antimicrobial agents
Catalysts
Efficiency
Ethylene
Ligands
Pharmaceutical industry
R&D
Research & development
United States > US
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Summary:The newly developed Piers' first-generation catalysts and Piers' second-generation catalysts are highly efficient for several olefin-metathesis processes, including ethenolysis and ring-closing metathesis. The high proficiency of these catalysts is attributed to the unique 4-coordinate, 14-electron structure, which allows for more facile catalyst initiation compared with the 5-coordinate Grubbs- and Hoveyda-type catalysts. The high activity of Piers catalysts, observed even at low temperatures, makes them ideal candidates for applications where low temperatures are desirable and double-bond migration is to be minimized. The authors describe the Piers' catalysts and detail latest progress in olefin-metathesis catalyst technology for applications in the pharmaceutical and fine-chemical industries. [PUBLICATION ABSTRACT]
ISSN:1543-2521
2150-7376