P185(c-neu) and Epidermal Growth Factor Receptor Associate into a Structure Composed of Activated Kinases

Research suggests that the heterodimer is an active complex composed of two activated kinases that may have an important role in signal transduction related to cell growth and transformation. Heterodimers generated higher protein kinase activities in vitro, and an isolated heterodimer was highly pho...

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 89; no. 4; p. 1330
Main Authors Qian, Xiaolan, Decker, Stuart J, Greene, Mark I
Format Journal Article
LanguageEnglish
Published Washington National Academy of Sciences 15.02.1992
Subjects
Biochemistry
Enzymes
Proteins
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Summary:Research suggests that the heterodimer is an active complex composed of two activated kinases that may have an important role in signal transduction related to cell growth and transformation. Heterodimers generated higher protein kinase activities in vitro, and an isolated heterodimer was highly phosphorylated on tyrosine residues of receptor subunits in vivo.
ISSN:0027-8424
1091-6490