NIR-II-responsive AuNRs@SiO2–RB@MnO2 nanotheranostic for multimodal imaging-guided CDT/PTT synergistic cancer therapy

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 10; no. 22; pp. 4274 - 4284
• Main Authors: Wen, Changchun, Guo, Xiaolu, Gao, Cunji, Zhu, Zhongkai, Meng, Nianqi, Shen, Xing-Can, Liang, Hong
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 08.06.2022
• Subjects: Absorption; Cancer therapies; cancer therapy; Consumption; dyes; Electromagnetic absorption; energy; Fluorescence; Free radicals; Glutathione; heat; Hydroxyl radicals; Imaging; Manganese dioxide; nanosheets; Near infrared radiation; neoplasms; photothermotherapy; Reagents; Rhodamine; rhodamines; Silicon dioxide; Therapy; Tumor cells; Tumor microenvironment; Tumors
• ISSN: 2050-750X; 2050-7518; 2050-7518
• DOI: 10.1039/d1tb02807c

Specific tumor-responsive capabilities and efficient synergistic therapeutic performance are the keys to effective tumor treatment. Herein, AuNRs@SiO2–RB@MnO2 was developed as a new type of tumor-responsive nanotheranostic for multimodal imaging and synergistic chemodynamic/photothermal therapy. In AuNRs@SiO2–RB@MnO2, the SiO2 layer wraps the AuNRs, providing light absorption in the second near-infrared (NIR-II) region. The SiO2 layer also adsorbs the MnO2 nanosheets, which have Fenton-like activity, resulting in a fluorescent sensing platform based on the fluorescence quenching properties of MnO2 for rhodamine B dye. The fluorescence can be recovered by the consumption of MnO2 by glutathione, which simultaneously produces Mn2+ in the tumor region. The recovery of fluorescence reflects the consumption of glutathione and the increase in Mn2+, which produces hydroxyl radicals via Fenton-like reaction in the tumor microenvironment to realize chemodynamic therapy. Meanwhile, the AuNRs are a good photothermal reagent that can effectively absorb NIR-II light and convert it into heat energy to kill tumor cells via photothermal therapy. The NIR-II absorption performance of the AuNRs provides good photoacoustic imaging and deep photothermal performance, which is favorable for efficient NIR-II photoacoustic imaging-guided photothermal therapy. As a result, the AuNRs@SiO2–RB@MnO2 nanotheranostic exhibits outstanding imaging and synergistic chemodynamic/photothermal therapeutic performance for tumor imaging and treatment.