An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing InVitro and InVivo

An amphiphilic dendrimer bearing a hydrophobic alkyl chain and hydrophilic poly(amidoamine) dendrons is able to combine the advantageous features of lipid and dendrimer vectors to deliver a heat shock protein27 siRNA and produce potent gene silencing and anticancer activity invitro and invivo in a p...

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Published inAngewandte Chemie International Edition Vol. 51; no. 34; pp. 8478 - 8484
Main Authors Yu, Tianzhu, Liu, Xiaoxuan, Bolcato-Bellemin, Anne-Laure, Wang, Yang, Liu, Cheng, Erbacher, Patrick, Qu, Fanqi, Rocchi, Palma, Behr, Jean-Paul, Peng, Ling
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.08.2012
EditionInternational ed. in English
Subjects
Anticancer properties
Dendrimers
Genes
Heat shock
Lipids
Mathematical analysis
Prostate
Vectors (mathematics)
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Summary:An amphiphilic dendrimer bearing a hydrophobic alkyl chain and hydrophilic poly(amidoamine) dendrons is able to combine the advantageous features of lipid and dendrimer vectors to deliver a heat shock protein27 siRNA and produce potent gene silencing and anticancer activity invitro and invivo in a prostate cancer model (see picture). This dendrimer can be used alternatively for treating various diseases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203920