Development of 3D-printed PLGA/TiO 2 nanocomposite scaffolds for bone tissue engineering applications

• Published in: Materials science & engineering. C, Materials for biological applications Vol. 96; p. 105
• Main Authors: Rasoulianboroujeni, M, Fahimipour, F, Shah, P, Khoshroo, K, Tahriri, M, Eslami, H, Yadegari, A, Dashtimoghadam, E, Tayebi, L
• Format: Journal Article
• Language: English
• Published: Netherlands 01.03.2019
• Subjects: Cell Line; Humans; Materials Testing; Nanocomposites - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry; Printing, Three-Dimensional; Tissue Engineering - methods; Tissue Scaffolds - chemistry; Titanium - chemistry; Wettability; Nanocomposite scaffold; PLGA; TiO; 3D-printing; Tissue engineering
• ISSN: 1873-0191
• DOI: 10.1016/j.msec.2018.10.077

Porous scaffolds were 3D-printed using poly lactic-co-glycolic acid (PLGA)/TiO composite (10:1 weight ratio) for bone tissue engineering applications. Addition of TiO nanoparticles improved the compressive modulus of scaffolds. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) revealed an increase in both glass transition temperature and thermal decomposition onset of the composite compared to pure PLGA. Furthermore, addition of TiO was found to enhance the wettability of the surface evidenced by reducing the contact angle from 90.5 ± 3.2 to 79.8 ± 2.4 which is in favor of cellular attachment and activity. The obtained results revealed that PLGA/TiO scaffolds significantly improved osteoblast proliferation compared to pure PLGA (p < 0.05). Furthermore, osteoblasts cultured on PLGA/TiO nanocomposite showed significantly higher ALP activity and improved calcium secretion compared to pure PLGA scaffolds (p < 0.05).