Effects on erectile function of transplanted major pelvic ganglion into the corpus cavernosum of adult rats with bilateral cavernous nerve injury

• Published in: Chung-hua wai kʿo tsa chih Vol. 42; no. 10; p. 596
• Main Authors: Cui, Dian-sheng, Hu, Li-quan, Li, Shi-wen, Zheng, Xin-min
• Format: Journal Article
• Language: Chinese
• Published: China 22.05.2004
• Subjects: Animals; Autonomic Denervation; Celiac Plexus - surgery; Ganglia, Autonomic - transplantation; Graft Survival; Male; Nitric Oxide Synthase - metabolism; Penile Erection - physiology; Penis - innervation; Penis - surgery; Rats; Rats, Sprague-Dawley; Transplantation, Autologous
• ISSN: 0529-5815

To investigate the effects on erectile function of transplanted major pelvic ganglion into the corpus cavernosum of adult male rats undergoing transection of bilateral cavernous nerves. Twenty-six male Sprague-Dawley rats (3 - 4 month-old and 300 - 400 g/each) were divided into 2 groups: experimental group (transection of bilateral cavernous nerves and transplantation of left ganglion into left crus of penis, n = 16) and control group (transection of bilateral cavernous nerves only, n = 10). Erectile function was measured by injecting APO, and intracavernous pressure was measured 1 and 3 months afterwards by electric-stimulating the right major pelvic ganglion or the left crus. Half animals in each group were sacrificed 1 and 3 months afterwards for detecting nNOS-containing nerve fibers of corpus cavernosum. Electron microscopy of the implanted area was performed to assess neuronal survival. Both of the two groups have no erectile response to APO injection. Electrostimulation on the right major pelvic gangli