Construction of β-cyclodextrin-based supramolecular hyperbranched polymers self-assemblies using AB 2 -type macromonomer and their application in the drug delivery field
Despite some efforts have been made in the research of supramolecular hyperbranched polymers (SHPs) self-assemblies, the study which has not been consideration to date is the influence of incoming stimuli-responsive polymer chain on their self-assembly property undergo outer stimuli. The introductio...
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Published in | Carbohydrate polymers Vol. 213; p. 411 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.06.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Despite some efforts have been made in the research of supramolecular hyperbranched polymers (SHPs) self-assemblies, the study which has not been consideration to date is the influence of incoming stimuli-responsive polymer chain on their self-assembly property undergo outer stimuli. The introduction of stimuli-responsive segments which could maintain their hydrophilic property are expected to affect the self-assembly behaviour of SHPs and expand their further biomedical application. In this paper, AB
-type macromolecular monomer, LA-(CD-PDMA)
, which consisted one lithocholic acid (LA) and two β-cyclodextrin terminated poly(2-(dimethylamino)ethyl methacrylate) segments (CD-PDMA) was synthesized. LA-(CD-PDMA)
based SHP were obtained based on the host-guest inclusion interactions of CD/LA moietes and with PDMA as pH-responsive hydrophilic chains. As a control to study the influence of incoming PDMA chains, both LA-(CD-PDMA)
based SHPs-1 and LA-CD
based SHPs-2 self-assemblies were comparatively investiged through 2D
H NMR ROESY, transmission electron microscopy (TEM) and dynamic light scattering (DLS). The results suggested that except for the higher drug loading efficiency LA-(CD-PDMA)
based SHPs-1 pocessing, the release rates of SHPs-1 increased notably at pH 5.0 than that of pH 7.4 due to the repulsion and stretch of protonated PDMA chains while the release rates of SHPs-2 showed no obvious difference. Finally, basic cell experiments demonstrated that the SHPs based self-assemblies can be internalized into cancer cells, indicating their potential application in the drug delivery field. |
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ISSN: | 1879-1344 |
DOI: | 10.1016/j.carbpol.2019.03.017 |