Study on absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model

To study the absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model. The Caco-2 monolayer model was used to explore the effect of time and drug concentration on the absorption of puerarin and its nanoparticeles. The drug concentration was determined by high-performance liqui...

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Bibliographic Details
Published inZhong yao cai Vol. 32; no. 8; p. 1252
Main Authors Liu, Xi-Jing, Jia, Qiang, Wang, Cheng-Yuan, Wang, Nai-Li
Format Journal Article
LanguageChinese
Published China 01.08.2009
Subjects
Absorption
Biological Transport
Caco-2 Cells
Cell Membrane Permeability
Chromatography, High Pressure Liquid
Drug Carriers - chemistry
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacokinetics
Humans
Isoflavones - chemistry
Isoflavones - pharmacokinetics
Models, Biological
Nanoparticles - chemistry
Polyesters - chemistry
Pueraria - chemistry
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Summary:To study the absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model. The Caco-2 monolayer model was used to explore the effect of time and drug concentration on the absorption of puerarin and its nanoparticeles. The drug concentration was determined by high-performance liquid chromatography and the Papp was caculated. The puerarin-PLGA-NP could significantly improve the absorption of puerarin. Puerarin was not only absorbed simply through passive diffusion, but also had relations with high dispersion of nanoparticles, increase of affinity and interaction with intestinal mucous membrane. The main mechanism of puerarin and its nanoparticles across Caco-2 monolayer model is passive transference. Puerarin-NP could increase the absorption of the drug in intestinal epithlial.
ISSN:1001-4454